Differences in Total S-RBD Antibody SARS-CoV-2 Post-vaccination mRNA-1273 3rd Dosage (Heterologous Prime Booster) with Post-prime Vaccination Inactivated Whole Virus Two Doses (Homologous) in Health Personnel Surabaya H2LC Clinic

SARS-CoV-2 cases have increased to 463,182,124 reported worldwide as of March 16, 2022 with a death toll 6,079,600. Indonesia on 17, has by 5,939,082 153,212 (KPCPEN, 2022). is closely related the coronavirus. One efforts made prevent risk severe infection and reduce rate from virus in vaccination program. According IDI (2021) Covid-19 deaths are dominated men (84%) women (16%). Clinical trials China Brazil shown that, immunogenicity two doses vaccine decreases over time there decrease low antibody concentrations after 6 months running time. To overcome this potential, Indonesian government gives priority 3rd booster. The purpose study was analyze comparison between total titer for Spike-RBD (Receptor Binding Domain) protein dose mRNA-1273 booster post-vaccination primary inactivated whole health workers. This research conducted observation cohort approach. It concluded that results Mann Whitney two-sided test significance value 0.000, correlation gender had 0.702 -0.366 relationship age. There significant difference 2 CoronaVac (booster) mRNA-1273, strongly associated S-RBD age not titer.